Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors

The in vitro binding of monomeric, dimeric and multimeric forms of monoclonal IgG1 molecules, designated mAb1 and mAb2, to the extracellular domains of Fcγ receptors RI, RIIA and RIIIB were investigated using a surface plasmon resonance (SPR) based biosensor technique. Stable noncovalent and covalen...

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Bibliografiske detaljer
Main Authors: Luo, Yin, Lu, Zhaojiang, Raso, Stephen W, Entrican, Clifford, Tangarone, Bruce
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2009
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759499/
https://ncbi.nlm.nih.gov/pubmed/20065648
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