Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody

Recombinant protein therapeutics have become increasingly useful in combating human diseases, such as cancer and those of genetic origin. One quality concern for protein therapeutics is the content and the structure of the aggregated proteins in the product, due to the potential immunogenicity of th...

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Pubblicato in:MAbs
Autori principali: Luo, Yin, Raso, Stephen W., Gallant, Judith, Steinmeyer, Colleen, Mabuchi, Yasuko, Lu, Zhaojiang, Entrican, Clifford, Rouse, Jason C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540114/
https://ncbi.nlm.nih.gov/pubmed/28590212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1331803
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