Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody

Recombinant protein therapeutics have become increasingly useful in combating human diseases, such as cancer and those of genetic origin. One quality concern for protein therapeutics is the content and the structure of the aggregated proteins in the product, due to the potential immunogenicity of th...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Luo, Yin, Raso, Stephen W., Gallant, Judith, Steinmeyer, Colleen, Mabuchi, Yasuko, Lu, Zhaojiang, Entrican, Clifford, Rouse, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540114/
https://ncbi.nlm.nih.gov/pubmed/28590212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1331803
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