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Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding
Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections, but exacerbates certain autoimmune diseases. The sole high-affinity IgG receptor, FcγRI plays a significant role in immunotherapy. To elucidate the molecular mechanism of its high-affinity IgG binding, we de...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4311811/ https://ncbi.nlm.nih.gov/pubmed/25561553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418812112 |
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