Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections, but exacerbates certain autoimmune diseases. The sole high-affinity IgG receptor, FcγRI plays a significant role in immunotherapy. To elucidate the molecular mechanism of its high-affinity IgG binding, we de...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lu, Jinghua, Chu, Jonathan, Zou, Zhongcheng, Hamacher, Nels B., Rixon, Mark W., Sun, Peter D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311811/
https://ncbi.nlm.nih.gov/pubmed/25561553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418812112
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