Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits modest yet relatively broad neutralization activity. Both binding and neutralization depend on residues in the complementarity determining regions...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Montgomery, Donna L, Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D, Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M, Finnefrock, Adam C, Strohl1, William, An, Zhiqiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2009
Gaiak:
Reports
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759496/
https://ncbi.nlm.nih.gov/pubmed/20065653
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