Antibacterial Activity of Berberine-NorA Pump Inhibitor Hybrids with a Methylene Ether Linking Group

Conjugation of the NorA substrate berberine and the NorA inhibitor 5-nitro-2-phenyl-1H-indole via a methylene ether linking group gave the 13-substituted berberine-NorA inhibitor hybrid, 3. A series of simpler arylmethyl ether hybrid structures were also synthesized. The hybrid 3 showed excellent an...

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Autori principali: Samosorn, Siritron, Tanwirat, Bongkot, Muhamad, Nussara, Casadei, Gabriele, Tomkiewicz, Danuta, Lewis, Kim, Suksamrarn, Apichart, Prammananan, Therdsak, Gornall, Karina C., Beck, Jennifer L., Bremner, John B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759347/
https://ncbi.nlm.nih.gov/pubmed/19419877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.04.028
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