Structure–Activity Relationships of 2-Aryl-1H-indole Inhibitors of the NorA Efflux Pump in Staphylococcus aureus

The synthesis of 22 2-aryl-1H-indoles, including 12 new compounds, has been achieved via Pd- or Rh- mediated methodologies, or selective electrophilic substitution. All three methods were based on elaborations from simple indole precursors. SAR studies on these indoles and 2-phenyl-1H-indole in S. a...

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Hlavní autoři: Ambrus, Joseph I., Kelso, Michael J., Bremner, John B., Ball, Anthony R., Casadei, Gabriele, Lewis, Kim
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590755/
https://ncbi.nlm.nih.gov/pubmed/18632270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.06.093
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