Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

The bacterial PorB porin, an ATP-binding β-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (ΔΨ(m)). Here, we show that P...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kozjak-Pavlovic, Vera, Dian-Lothrop, Elke A., Meinecke, Michael, Kepp, Oliver, Ross, Katharina, Rajalingam, Krishnaraj, Harsman, Anke, Hauf, Eva, Brinkmann, Volker, Günther, Dirk, Herrmann, Ines, Hurwitz, Robert, Rassow, Joachim, Wagner, Richard, Rudel, Thomas
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2009
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759283/
https://ncbi.nlm.nih.gov/pubmed/19851451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000629
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