Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

The bacterial PorB porin, an ATP-binding β-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (ΔΨ(m)). Here, we show that P...

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Detalhes bibliográficos
Main Authors: Kozjak-Pavlovic, Vera, Dian-Lothrop, Elke A., Meinecke, Michael, Kepp, Oliver, Ross, Katharina, Rajalingam, Krishnaraj, Harsman, Anke, Hauf, Eva, Brinkmann, Volker, Günther, Dirk, Herrmann, Ines, Hurwitz, Robert, Rassow, Joachim, Wagner, Richard, Rudel, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759283/
https://ncbi.nlm.nih.gov/pubmed/19851451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000629
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