Point Mutations in GLI3 Lead to Misregulation of its Subcellular Localization

BACKGROUND: Mutations in the transcription factor GLI3, a downstream target of Sonic Hedgehog (SHH) signaling, are responsible for the development of malformation syndromes such as Greig-cephalopolysyndactyly-syndrome (GCPS), or Pallister-Hall-syndrome (PHS). Mutations that lead to loss of function...

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Detalhes bibliográficos
Main Authors: Krauß, Sybille, So, Joyce, Hambrock, Melanie, Köhler, Andrea, Kunath, Melanie, Scharff, Constance, Wessling, Martina, Grzeschik, Karl-Heinz, Schneider, Rainer, Schweiger, Susann
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758996/
https://ncbi.nlm.nih.gov/pubmed/19829694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007471
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