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Asymmetric Carbon–Carbon Bond Formation γ to a Carbonyl Group: Phosphine-Catalyzed Addition of Nitromethane to Allenes

[Image: see text] A chiral phosphine catalyzes the addition of a carbon nucleophile to the γ position of an electron-poor allene (amide-, ester-, or phosphonate-substituted), in preference to isomerization to a 1,3-diene, in good ee and yield. This strategy provides an attractive method for the cata...

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書目詳細資料
Main Authors: Smith, Sean W., Fu, Gregory C.
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758928/
https://ncbi.nlm.nih.gov/pubmed/19772285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9061823
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