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C-1027, a radiomimetic enediyne anti-cancer drug, preferentially targets hypoxic cells
The hypoxic nature of cells within solid tumors limits the efficacy of anti-cancer therapies such as ionizing radiation and conventional radiomimetics because their mechanisms require oxygen to induce lethal DNA breaks. For example, the conventional radiomimetic enediyne neocarzinostatin is 4 fold l...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758494/ https://ncbi.nlm.nih.gov/pubmed/19147573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2753 |
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