A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-synonymous single nucleotide polymorphisms in its coding region. We...

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Main Authors: Nagpal, Kamalpreet, Plantinga, Theo S., Wong, Joyce, Monks, Brian G., Gay, Nicholas J., Netea, Mihai G., Fitzgerald, Katherine A., Golenbock, Douglas T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Mechanisms of Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757976/
https://ncbi.nlm.nih.gov/pubmed/19509286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014886
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