CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As purinergic mediators have been implicated in intestinal inflammation, we hypothesized that CD39 might protect against inflammatory bowel disease. We studied these possibilities in a mouse model of colitis using mice with gl...

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Detalhes bibliográficos
Main Authors: Friedman, David J., Künzli, Beat M., A-Rahim, Yousif I., Sevigny, Jean, Berberat, Pascal O., Enjyoji, Keiichi, Csizmadia, Eva, Friess, Helmut, Robson, Simon C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757811/
https://ncbi.nlm.nih.gov/pubmed/19805374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902869106
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