Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

In cancer, genetically activated proto-oncogenes often induce “upstream” dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce massive apoptosis of tumor cells, leading to sometimes dramatic tumor regressions in patients. The PI3K and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, Heynck, Stefanie, Stückrath, Isabel, Weiss, Jonathan, Fischer, Florian, Michel, Kathrin, Goel, Aviva, Regales, Lucia, Politi, Katerina A., Perera, Samanthi, Getlik, Matthäus, Heukamp, Lukas C., Ansén, Sascha, Zander, Thomas, Beroukhim, Rameen, Kashkar, Hamid, Shokat, Kevan M., Sellers, William R., Rauh, Daniel, Orr, Christine, Hoeflich, Klaus P., Friedman, Lori, Wong, Kwok-Kin, Pao, William, Thomas, Roman K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757399/
https://ncbi.nlm.nih.gov/pubmed/19805051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907325106
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia