Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

In cancer, genetically activated proto-oncogenes often induce “upstream” dependency on the activity of the mutant oncoprotein. Therapeutic inhibition of these activated oncoproteins can induce massive apoptosis of tumor cells, leading to sometimes dramatic tumor regressions in patients. The PI3K and...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Sos, Martin L., Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M., Koker, Mirjam, Heynck, Stefanie, Stückrath, Isabel, Weiss, Jonathan, Fischer, Florian, Michel, Kathrin, Goel, Aviva, Regales, Lucia, Politi, Katerina A., Perera, Samanthi, Getlik, Matthäus, Heukamp, Lukas C., Ansén, Sascha, Zander, Thomas, Beroukhim, Rameen, Kashkar, Hamid, Shokat, Kevan M., Sellers, William R., Rauh, Daniel, Orr, Christine, Hoeflich, Klaus P., Friedman, Lori, Wong, Kwok-Kin, Pao, William, Thomas, Roman K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2009
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757399/
https://ncbi.nlm.nih.gov/pubmed/19805051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907325106
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