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Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A(164) driven angiogenesis, in part by blocking S6Kinase
OBJECTIVE: We evaluated the stages of VEGF-A(164) driven angiogenesis that are inhibited by therapeutic doses of rapamycin and the potential role of S6K1 in that response. METHODS AND RESULTS: We assessed the effects of rapamycin on the several stages of angiogensis and lymphangiogenesis induced wit...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756965/ https://ncbi.nlm.nih.gov/pubmed/19443844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.185918 |
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