Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking

Cholesterol plays a key role in membrane protein function and signaling in endothelial cells. Thus, disturbing cholesterol trafficking is an effective approach for inhibiting angiogenesis. We recently identified astemizole (AST), an antihistamine drug, as a cholesterol trafficking inhibitor from a p...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Lyu, Junfang, Yang, Eun Ju, Head, Sarah A., Ai, Nana, Zhang, Baoyuan, Wu, Changjie, Li, Ruo-Jing, Liu, Yifan, Chakravarty, Harapriya, Zhang, Shaolin, Tam, Kin Yip, Dang, Yongjun, Kwon, Ho Jeong, Ge, Wei, Liu, Jun O., Shim, Joong Sup
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097475/
https://ncbi.nlm.nih.gov/pubmed/30123067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.26011
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