Structure-Activity Relationship and Metabolic Stability Studies of Backbone Cyclization and N-Methylation of Melanocortin Peptides

Backbone cyclization (BC) and N-methylation have been shown to enhance the activity and/or selectivity of biologically active peptides and improve metabolic stability and intestinal permeability. In this study, we describe the synthesis, structure-activity relationship (SAR) and intestinal metabolic...

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Main Authors: Linde, Yaniv, Ovadia, Oded, Safrai, Eli, Xiang, Zhimin, Portillo, Federico P., Shalev, Deborah E., Haskell-Luevano, Carrie, Hoffman, Amnon, Gilon, Chaim
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756785/
https://ncbi.nlm.nih.gov/pubmed/18655141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21057
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