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Discovery of Diphenyl Amine Based Sodium Channel Blockers, Effective Against hNa(v)1.2

The development of new therapies for chronic pain is an area of unmet medical need. Central to pathways of chronic pain is the upregulation of voltage gated sodium channels. The use of tricyclic antidepressants, which also have sodium channel activity, in chronic pain therapy prompted us to develop...

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Библиографические подробности
Главные авторы: Hudgens, Debjani P., Taylor, Catherine, Batts, Timothy W., Patel, Manoj K., Brown, Milton L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756728/
https://ncbi.nlm.nih.gov/pubmed/17035036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.09.010
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