The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo

BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARα, -β/δ, and -γ) nuclear receptors. In particular, PPARα is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPARα mediates the cardiac fasting response, increasing fatty acid met...

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Detalhes bibliográficos
Main Authors: Wray, Jessica A., Sugden, Mary C., Zeldin, Darryl C., Greenwood, Gemma K., Samsuddin, Salma, Miller-Degraff, Laura, Bradbury, J. Alyce, Holness, Mark J., Warner, Timothy D., Bishop-Bailey, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756622/
https://ncbi.nlm.nih.gov/pubmed/19823578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007421
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