Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

The mammalian target of rapamycin (mTOR) has emerged as an important therapeutic target for diffuse large B-cell lymphoma (DLBCL), as recent studies have demonstrated that 30% of relapsed patients respond to mTOR inhibitors. Why some lymphomas are resistant is incompletely understood. In the present...

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Main Authors: Gupta, Mamta, Ansell, Stephen M., Novak, Anne J., Kumar, Shaji, Kaufmann, Scott H., Witzig, Thomas E.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2009
主題:
Lymphoid Neoplasia
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756203/
https://ncbi.nlm.nih.gov/pubmed/19641186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-220889
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