Lack of specific γ-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation

Retroviral transduction of tumor antigen-specific T-cell receptor (TCR) genes into lymphocytes redirects T cells to lyse tumors. Furthermore, adoptive transfer of these lymphocytes has mediated objective responses in patients with metastatic cancer. From 2004 to 2006, more than 40 patients were trea...

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Detalles Bibliográficos
Main Authors: Burns, William R., Zheng, Zhili, Rosenberg, Steven A., Morgan, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2009
Assuntos:
Gene Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756199/
https://ncbi.nlm.nih.gov/pubmed/19589923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-01-199216
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