Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh)

Prior studies indicate that cholinergic receptor (ChR) activation is linked to beating rate reduction (BRR) in sinoatrial nodal cells (SANC) via 1) a G(i)-coupled reduction in adenylyl cyclase (AC) activity, leading to a reduction of cAMP or protein kinase A (PKA) modulation of hyperpolarization-act...

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Huvudupphovsmän: Lyashkov, Alexey E., Vinogradova, Tatiana M., Zahanich, Ihor, Li, Yue, Younes, Antoine, Nuss, H. Bradley, Spurgeon, Harold A., Maltsev, Victor A., Lakatta, Edward G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2009
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755991/
https://ncbi.nlm.nih.gov/pubmed/19542482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01340.2008
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