Ca(2+)-stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal Pacemaker Cells

Spontaneous, rhythmic subsarcolemmal local Ca(2+) releases driven by cAMP-mediated, protein kinase A (PKA)-dependent phosphorylation are crucial for normal pacemaker function of sinoatrial nodal cells (SANC). Because local Ca(2+) releases occur beneath the cell surface membrane, near to where adenyl...

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Detalhes bibliográficos
Main Authors: Younes, Antoine, Lyashkov, Alexey E., Graham, David, Sheydina, Anna, Volkova, Maria V., Mitsak, Megan, Vinogradova, Tatiana M., Lukyanenko, Yevgeniya O., Li, Yue, Ruknudin, Abdul M., Boheler, Kenneth R., van Eyk, Jennifer, Lakatta, Edward G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386925/
https://ncbi.nlm.nih.gov/pubmed/18356168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707540200
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