Ca(2+)-stimulated Basal Adenylyl Cyclase Activity Localization in Membrane Lipid Microdomains of Cardiac Sinoatrial Nodal Pacemaker Cells

Spontaneous, rhythmic subsarcolemmal local Ca(2+) releases driven by cAMP-mediated, protein kinase A (PKA)-dependent phosphorylation are crucial for normal pacemaker function of sinoatrial nodal cells (SANC). Because local Ca(2+) releases occur beneath the cell surface membrane, near to where adenyl...

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Autors principals: Younes, Antoine, Lyashkov, Alexey E., Graham, David, Sheydina, Anna, Volkova, Maria V., Mitsak, Megan, Vinogradova, Tatiana M., Lukyanenko, Yevgeniya O., Li, Yue, Ruknudin, Abdul M., Boheler, Kenneth R., van Eyk, Jennifer, Lakatta, Edward G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386925/
https://ncbi.nlm.nih.gov/pubmed/18356168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707540200
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