Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca(2+)/Ca(2+)/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways

The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the underlying molecular mechanism remains unknown. Here we show that in muscle cells adiponectin and metformin induce AMPK activation...

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Lijun, Deepa, Sathyaseelan S., Etzler, Julie C., Ryu, Jiyoon, Mao, Xuming, Fang, Qichen, Liu, Dianna D., Torres, Jesus M., Jia, Weiping, Lechleiter, James D., Liu, Feng, Dong, Lily Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755964/
https://ncbi.nlm.nih.gov/pubmed/19520843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028357
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