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Adiponectin Activates AMP-activated Protein Kinase in Muscle Cells via APPL1/LKB1-dependent and Phospholipase C/Ca(2+)/Ca(2+)/Calmodulin-dependent Protein Kinase Kinase-dependent Pathways
The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the underlying molecular mechanism remains unknown. Here we show that in muscle cells adiponectin and metformin induce AMPK activation...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2755964/ https://ncbi.nlm.nih.gov/pubmed/19520843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028357 |
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