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Nucleotide sequence homology requirements of HIV-1-specific short hairpin RNA

The degradation of a selected mRNA species by RNA interference requires a high degree of homology between the short interfering or short hairpin RNA (si or shRNA) and its target. Recent reports have demonstrated that the number and location of nucleotide mismatches affect the activity of si/shRNA. H...

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Bibliografski detalji
Glavni autori: Pusch, Oliver, Boden, Daniel, Silbermann, Rebecca, Lee, Fred, Tucker, Lynne, Ramratnam, Bharat
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC275570/
https://ncbi.nlm.nih.gov/pubmed/14602902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg876
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