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Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase
PDK1 (phosphoinositide-dependent protein kinase-1) catalyzes phosphorylation of Thr-229 in the T-loop of S6K1αII (the 70-kDa 40 S ribosomal protein S6 kinase-1 αII isoform), and Thr-229 phosphorylation is synergistic with C-terminal Thr-389 phosphorylation to activate S6K1αII regulatory functions in...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2755668/ https://ncbi.nlm.nih.gov/pubmed/19570988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032177 |
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