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Kinetic Mechanism of Fully Activated S6K1 Protein Kinase

S6K1 is a member of the AGC subfamily of serine-threonine protein kinases, whereby catalytic activation requires dual phosphorylation of critical residues in the conserved T-loop (Thr-229) and hydrophobic motif (Thr-389). Previously, we described production of the fully activated catalytic kinase do...

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Autori principali: Keshwani, Malik M., Harris, Thomas K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335363/
https://ncbi.nlm.nih.gov/pubmed/18326039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800114200
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