Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)

p70 ribosomal protein S6 kinase 1 (S6K1) is regulated by multiple phosphorylation events. Three of these sites are highly conserved among AGC kinases (cAMP dependent Protein Kinase, cGMP dependent Protein Kinase, and Protein Kinase C subfamily): the activation loop in the kinase domain, and two C-te...

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Detalles Bibliográficos
Main Authors: Keshwani, Malik M., von Daake, Sventja, Newton, Alexandra C., Harris, Thomas K., Taylor, Susan S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123118/
https://ncbi.nlm.nih.gov/pubmed/21561857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.258004
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