Mechanism of PDK1-catalyzed Thr-229 Phosphorylation of the S6K1 Protein Kinase

PDK1 (phosphoinositide-dependent protein kinase-1) catalyzes phosphorylation of Thr-229 in the T-loop of S6K1αII (the 70-kDa 40 S ribosomal protein S6 kinase-1 αII isoform), and Thr-229 phosphorylation is synergistic with C-terminal Thr-389 phosphorylation to activate S6K1αII regulatory functions in...

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Bibliographic Details
Main Authors: Keshwani, Malik M., Gao, Xinxin, Harris, Thomas K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755668/
https://ncbi.nlm.nih.gov/pubmed/19570988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032177
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