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DNA–protein cross-linking by trans-[PtCl(2)(E-iminoether)(2)]. A concept for activation of the trans geometry in platinum antitumor complexes

The structure–pharmacological activity relationships generally accepted for antitumor platinum compounds stressed the necessity for the cis-[PtX(2)(amine)(2)] structure while the trans-[PtX(2)(amine)(2)] structure was considered inactive. However, more recently, several trans-platinum complexes have...

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Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Novakova, Olga, Kasparkova, Jana, Malina, Jaroslav, Natile, Giovanni, Brabec, Viktor
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275558/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14602903/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg863
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