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Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism
The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase essential for the completion of mitosis in all eukaryotic cells. Substrates are recruited to the APC/C by activator proteins (Cdc20 or Cdh1), but it is not known where substrates are bound during catalysis. We explored this pr...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754851/ https://ncbi.nlm.nih.gov/pubmed/19362536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.02.027 |
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