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Cold-sensitive mutants of Taq DNA polymerase provide a hot start for PCR

Although the thermophilic bacterium Thermus aquaticus grows optimally at 70°C and cannot grow at moderate temperatures, its DNA polymerase I has significant activity at 20–37°C. This activity is a bane to some PCRs, since it catalyzes non-specific priming. We report mutations of Klentaq (an N-termin...

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Bibliografski detalji
Glavni autori: Kermekchiev, Milko B., Tzekov, Anatoly, Barnes, Wayne M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC275455/
https://ncbi.nlm.nih.gov/pubmed/14576300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg813
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