Inhibition of Bacterial Rna Polymerase by Streptolydigin: Stabilization of A Straight-Bridge-Helix Active-Center Conformation

We define the target, mechanism, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the tetramic-acid antibiotic streptolydigin (Stl). Stl binds to a site adjacent to, but not overlapping, the RNAP active center and stabilizes an RNAP-active-center conformational state with a s...

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Библиографические подробности
Главные авторы: Tuske, Steven, Sarafianos, Stefan G., Wang, Xinyue, Hudson, Brian, Sineva, Elena, Mukhopadhyay, Jayanta, Birktoft, Jens J., Leroy, Olivier, Ismail, Sajida, Clark, Arthur D., Dharia, Chhaya, Napoli, Andrew, Laptenko, Oleg, Lee, Jookyung, Borukhov, Sergei, Ebright, Richard H., Arnold, Eddy
Формат: Artigo
Язык:Inglês
Опубликовано: 2005
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754413/
https://ncbi.nlm.nih.gov/pubmed/16122422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2005.07.017
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