THE RNA POLYMERASE “SWITCH REGION” IS A TARGET FOR INHIBITORS

We report the target, biochemical basis, and structural basis of inhibition of bacterial RNA polymerase (RNAP) by the α-pyrone antibiotic myxopyronin (Myx). We show that Myx interacts with the RNAP “switch region,” the hinge that mediates opening and closing of the RNAP active-center cleft. We show...

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Detalhes bibliográficos
Main Authors: Mukhopadhyay, Jayanta, Das, Kalyan, Ismail, Sajida, Koppstein, David, Jang, Minyoung, Hudson, Brian, Sarafianos, Stefan, Tuske, Steven, Patel, Jay, Jansen, Rolf, Irschik, Herbert, Arnold, Eddy, Ebright, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580802/
https://ncbi.nlm.nih.gov/pubmed/18957204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.033
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