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Bacterial RNA Polymerase-DNA Interaction—The Driving Force of Gene Expression and the Target for Drug Action

DNA-dependent multisubunit RNA polymerase (RNAP) is the key enzyme of gene expression and a target of regulation in all kingdoms of life. It is a complex multifunctional molecular machine which, unlike other DNA-binding proteins, engages in extensive and dynamic interactions (both specific and nonsp...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Lee, Jookyung, Borukhov, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101437/
https://ncbi.nlm.nih.gov/pubmed/27882317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00073
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