Impact Of Pro Segments On The Folding And Function Of Human Neutrophil α-Defensins

Human neutrophil α-defensins (HNPs) are synthesized in vivo as inactive precursor proteins, i.e., preproHNPs. A series of sequential proteolytic events excise the N-terminal inhibitory pro peptide, leading to defensin maturation and storage in azurophilic granules. The anionic pro peptide, required...

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Bibliographische Detailangaben
Hauptverfasser: Wu, Zhibin, Li, Xiangqun, Ericksen, Bryan, de Leeuw, Erik, Zou, Guozhang, Zeng, Pengyun, Xie, Cao, Li, Cong, Lubkowski, Jacek, Lu, Wei-Yue, Lu, Wuyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754399/
https://ncbi.nlm.nih.gov/pubmed/17355880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.040
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