Lack of regulation of 11β-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism

OBJECTIVE: Evidence from long-term clinical studies measuring urinary steroid ratios, and from in vitro studies, suggests that GH administered for longer than 2 months down-regulates 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby reducing cortisol regeneration in liver and adipose tissu...

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Hlavní autoři: Sigurjonsdottir, Helga A, Andrew, Ruth, Stimson, Roland H, Johannsson, Gudmundur, Walker, Brian R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioScientifica 2009
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754375/
https://ncbi.nlm.nih.gov/pubmed/19549748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-09-0315
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