TβRI Independently Activates Smad- and CD2AP-Dependent Pathways in Podocytes

TGF-β regulates differentiation, growth, and apoptosis of podocytes and mediates podocyte depletion in glomerulosclerosis. TGF-β promotes proapoptotic signaling mediated by Smad3 but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-associa...

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Detalhes bibliográficos
Main Authors: Xavier, Sandhya, Niranjan, Thiruvur, Krick, Stefanie, Zhang, Taoran, Ju, Wenjun, Shaw, Andrey S., Schiffer, Mario, Böttinger, Erwin P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2009
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754100/
https://ncbi.nlm.nih.gov/pubmed/19679673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008070806
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