Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

Considerable effort has focused on the development of selective protein farnesyl transferase (FTase) and protein geranylgeranyl transferase (GGTase) inhibitors as cancer chemotherapeutics. Here, we report a new strategy for anti-cancer therapeutic agents involving inhibition of farnesyl diphosphate...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhang, Yonghui, Cao, Rong, Yin, Fenglin, Hudock, Michael P., Guo, Rey-Ting, Krysiak, Kilannin, Mukherjee, Sujoy, Gao, Yi-Gui, Robinson, Howard, Song, Yongcheng, No, Joo Hwan, Bergan, Kyle, Leon, Annette, Cass, Lauren, Goddard, Amanda, Chang, Ting-Kai, Lin, Fu-Yang, Van Beek, Ermond, Papapoulos, Socrates, Wang, Andrew H.-J., Kubo, Tadahiko, Ochi, Mitsuo, Mukkamala, Dushyant, Oldfield, Eric
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753403/
https://ncbi.nlm.nih.gov/pubmed/19309137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808285e
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