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Trifluoperazine: a ryanodine receptor agonist
Trifluoperazine (TFP), a phenothiazine, is a commonly used antipsychotic drug whose therapeutic effects are attributed to its central anti-adrenergic and antidopaminergic actions. However, TFP is also a calmodulin (CaM) antagonist and alters the Ca binding properties of calsequestrin (CSQ). The CaM...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752966/ https://ncbi.nlm.nih.gov/pubmed/19277699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-009-0658-y |
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