Single Ryanodine Receptor Channel Basis of Caffeine's Action on Ca(2+) Sparks

Caffeine (1, 3, 7-trimethylxanthine) is a widely used pharmacological agonist of the cardiac ryanodine receptor (RyR2) Ca(2+) release channel. It is also a well-known stimulant that can produce adverse side effects, including arrhythmias. Here, the action of caffeine on single RyR2 channels in bilay...

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Autors principals: Porta, Maura, Zima, Aleksey V., Nani, Alma, Diaz-Sylvester, Paula L., Copello, Julio A., Ramos-Franco, Josefina, Blatter, Lothar A., Fill, Michael
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
Matèries:
Channels and Transporters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037573/
https://ncbi.nlm.nih.gov/pubmed/21320437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.01.017
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