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The balancing act: Inhibitory Ly49 regulate NKG2D-mediated NK cell functions

NK cells use NKG2D receptor to recognize ‘induced-self’. In apparent violation of the ‘missing-self’ hypothesis, NK cells stimulated through NKG2D can lyse target cells despite normal expression levels of MHC class I molecules. Although, ‘overriding’ of the inhibitory by the activating signals had b...

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Autore principale: Malarkannan, Subramaniam
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752866/
https://ncbi.nlm.nih.gov/pubmed/16737823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2006.04.002
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