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Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity
During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2]. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical spindle assembly factors [3–5]. Here, we show in Xenopus egg extract,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752711/ https://ncbi.nlm.nih.gov/pubmed/19540121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.05.061 |
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