Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity

During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin [1, 2]. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical spindle assembly factors [3–5]. Here, we show in Xenopus egg extract,...

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Main Authors: Maresca, Thomas J., Groen, Aaron C., Gatlin, Jesse C., Ohi, Ryoma, Mitchison, Timothy J., Salmon, Edward D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752711/
https://ncbi.nlm.nih.gov/pubmed/19540121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.05.061
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