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Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
To date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation carriers, though these efforts are hampered by the high frequency of variants of unknow...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752086/ https://ncbi.nlm.nih.gov/pubmed/19770520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39836 |
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