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RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair...
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| Udgivet i: | Mol Oncol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7266267/ https://ncbi.nlm.nih.gov/pubmed/32255263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12679 |
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