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RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers
Adamson et al. report that BRCA2 mutation carriers inheriting RAD52 S346X variant have reduced breast cancer risk. The RAD52 S346X variant lacks the nuclear localization sequence, which mislocalizes the protein to the cytoplasm and renders it nonfunctional. Combined loss of BRCA2‐mediated DNA repair...
Enregistré dans:
| Publié dans: | Mol Oncol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7266267/ https://ncbi.nlm.nih.gov/pubmed/32255263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12679 |
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