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An arrestin-dependent multi-kinase signaling complex mediates MIP-1β/CCL4 signaling and chemotaxis of primary human macrophages

MIP-1β/CCL4 is a principal regulator of macrophage migration and signals through CCR5. Several protein kinases are linked to CCR5 in macrophages including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2, and members of the MAPK family, but whether and how these kinases regulate macropha...

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Autori principali: Cheung, Ricky, Malik, Mobeen, Ravyn, Vipa, Tomkowicz, Brian, Ptasznik, Andrzej, Collman, Ronald G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Society for Leukocyte Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752020/
https://ncbi.nlm.nih.gov/pubmed/19620252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0908551
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